【摘要】 采用在体蟾蜍上颚模型考察石杉碱甲(1)微乳鼻腔给药对蟾蜍上腭纤毛存活时间和输送能力的影响,并利用扫描电镜观察1微乳对大鼠鼻黏膜纤毛形态的影响。结果表明,与生理盐水组比较,1微乳对蟾蜍上腭纤毛存活时间无显著影响(P>0.05);与给药前相比,1微乳对蟾蜍上腭纤毛输送能力无显著改变(P>0.05)。扫描电镜结果表明,大鼠鼻黏膜纤毛与1微乳作用2 h,形态无明显改变,但灌流4 h时纤毛形态略有改变。提示1微乳鼻腔给药对鼻黏膜纤毛刺激性较小。更多还原

【Abstract】 The effects of huperzine A(1) microemulsion for nasal delivery on survival time and transporting ability of cilia were evaluated with in situ toad palate model. Meanwhile, the appearance of rat nasal mucosa cilia treated with 1 microemulsion was observed by scanning electron microscope(SEM). Compared with the saline group, the survival time of cilia on toad palate treated by 1 microemulsion had no significant differences(P>0.05). The transporting ability of cilia on toad palate before and after administration had no obvious changes(P>0.05). The observations of SEM analysis showed that the appearance of rat nasal mucosa cilia perfused with 1 microemulsion for 2 h had no obvious changes, but had a slight change after perfusion for 4 h. It indicated that the 1 microemulsion for nasal delivery had a minor irritation to the nasal mucosa cilia.更多还原