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低分子右旋糖酐氨基酸注射液中亚硫酸氢钠的离子色谱法测定
Determination of Sodium Bisulfite in Dextran 40 and Amino Acids Injection by Ion Chromatography
【摘要】 建立了离子色谱抑制电导法测定低分子右旋糖酐氨基酸注射液中的抗氧化剂亚硫酸氢钠。采用IonPac AS11-HC阴离子分析柱,以13 mmol/L氢氧化钾溶液为淋洗液,抑制型电导检测器检测。结果亚硫酸氢钠含量在3.75~60μg/ml之间线性关系良好,样品平均回收率为95.3%。
【Abstract】 A suppressed conductivity ion chromatography method was established for the determination of antioxidant sodium bisulfite in dextran 40 and amino acids injection.An IonPac ASll-HC anion column was used,with13 mmol/L potassium hydroxide solution as eluent and using suppressed conductivity detector.The calibration curve for sodium bisulfite was linear in the range of 3.75- 60 ng/ml.The average recovery was 95.3%.
【关键词】 低分子右旋糖酐氨基酸注射液;
亚硫酸氢钠;
离子色谱法;
测定;
【Key words】 dextran 40 and amino acids injection; sodium bisulfite; ion chromatography; determination;
【Key words】 dextran 40 and amino acids injection; sodium bisulfite; ion chromatography; determination;
- 【文献出处】 中国医药工业杂志 ,Chinese Journal of Pharmaceuticals , 编辑部邮箱 ,2014年02期
- 【分类号】TQ460.72;O657.7
- 【被引频次】1
- 【下载频次】141