【摘要】 [目的]了解福建省胃癌中低发地区居民血清PGⅠ、PGⅡ、G-17和Hp感染水平分布特征,探讨用上述血清学标志物筛查高危人群的可能性。[方法]在同安区和福安市随机抽取调查对象进行问卷调查,检测血清PGⅠ、PGⅡ、G-17和Hp感染水平。[结果]PGⅠ水平呈明显的性别、年龄、地区分布差异,PGⅡ、PGⅠ/PGⅡ水平呈明显的地区分布差异。不同Hp感染状态下PGⅠ、PGⅡ、PGⅠ/PGⅡ、G-17水平呈明显差异(P均<0.05)。Logistic回归分析未发现影响PGⅠ、PGⅠ/PGⅡ水平异常的因素,但G-17水平异常的危险因素为Hp感染(OR=2.656)和中年年龄(OR=2.114)。[结论]PGⅠ、PGⅡ、G-17筛查胃癌高危人群具有较广阔的前景。更多还原

【Abstract】 [Purpose] To investigate the distributing characteristics of serum PGⅠ,PGⅡ,G-17 and Hp infection in residents in areas with medium-low incidence of gastric cancer in Fujian,and the possibility of using serum markers screening high-risk groups. [Methods] The person being investigated randomly from Tongan district and Fuan city received the interview questionnaires and were detected serum PGⅠ,PGⅡ,G-17,Hp detection. [Results] PGⅠ level showed significant differences in gender,age,region distribution. PGⅡ,PGⅠ/ PG Ⅱ level also showed significant difference in region distribution. PGⅠ,PGⅡ,PGⅠ/PGⅡ,G-17 level were significantly different between positive Hp infection and negative Hp infection(all P<0.05). Logistic regression analysis showed no factor caused abnormal levels of PGⅠ,PGⅠ/PGⅡ,but Hp infection(OR=2.656) and middle aged(OR= 2.114) were high risks for G-17 abnormal levels. [Conclusion] PG Ⅰ,PG Ⅱ,G-17 have a broad prospect of screening for high-risk population with gastric cancer.更多还原