【摘要】 目的:观察托烷司琼对手术后曲马多自控静脉镇痛患者免疫功能的影响。方法:40例患者随机分为两组,术毕给负荷量后接PCIA泵;并于麻醉前、术毕、术后24、48 h检测CD3+、CD4+、CD8+、CD4+/CD8+及CD16+、CD56+/CD45+的变化。结果:对照组恶心呕吐发生率明显高于观察组(P<0.05);两组CD3+、CD4+淋巴细胞在术毕、术后24 h和48 h均较麻醉前明显降低(P<0.05),CD16+、CD56+/CD45+、CD4+/CD8+术毕及术后24 h也低于麻醉前(P<0.05);对照组在术后24 h CD16+、CD56+/CD45+、CD3+、CD4+、CD4+/CD8+明显增高(P<0.05);对照组在术后48 h CD16+、CD56+/CD45+、CD4+/CD8+已恢复到麻醉前水平。结论:预防性应用托烷司琼,能有效地减轻曲马多引起的恶心呕吐,但减弱其免疫保护功能。更多还原

【Abstract】 ObjectiveTo investigate the effect of Tropisetron Hydrochloride on the immune function of tramadol for postoperative patient-controlled intravenous analgesia.MethodsForty patients were randomly assigned into two groups, connecting the PCIA pump after given the load quantity. Blood samples were collected before induction of anaesthesia and after operation for 0 h, 24 h, 48 h, respectively. The T-lymphocyte subsets and natural killer cells(NK)were measured by flow cytometry.ResultsThe incidences of nausea and vomiting were higher in control group than those in observation group(P < 0.05). In both groups,the amounts of CD3+and CD4+lymphocytes decreased significantly at 0 h, 24 h and 48 h after operation than before anaesthesia(P < 0.05). the amounts of NK cells(CD16+、CD56+/CD45+) and CD4+/CD8+also decreased significantly at 0 h and 24 h after operation than before anaesthesia(P < 0.05). Compared to the observation group,the amounts of CD16+,CD56+/ CD45+, CD3+, CD4+and CD4+/CD8+increased significantly at 24 h after operation(P < 0.05). In control group, the amounts of CD16+, CD56+/CD45+and CD4+/CD8+recovered to preanaesthesia level at 48 h, while in observation group, they were still lower than preanaesthesia levels(P < 0.05).ConclusionTropisetron Hydrochloride reduces the incidence of vomiting induced by tramadol but not beneficial to recover the cell-immunity of patients suffering from gastric cancer surgery.更多还原