【摘要】 目的:比较酪蛋白磷酸多肽-无定形磷酸钙(CPP-ACP)的再矿化糊剂和Duraphat Varnish保护漆预防头颈部肿瘤患者放射性龋齿和牙本质敏感的疗效。方法:112例头颈部肿瘤患者,随机分为CPP-ACP再矿化糊剂组(实验组)和Duraphat Varnish保护漆组(对照组)。实验组:含900 ppm的CPP-ACP再矿化糊剂于放疗前1天起涂抹牙面,1次/天,疗程为5周;对照组:含5%氟化钠的Duraphat Varnish保护漆于放疗前1天起涂抹牙面,1次/天,疗程为5周。分别观察两组患者放疗前、放疗后12个月的龋失补牙数(DMFT)、龋失补牙面数(DMFS)和牙本质敏感程度并进行比较。结果:两组放疗前,DMFT、DMFS和牙本质敏感程度差异无统计学意义(P>0.05)。与放疗前比较,放疗后12个月两组DMFT、DMFS和牙本质敏感程度均明显升高,且对照组的DMFT、DMFS和牙本质敏感程度较实验组升高更明显(P<0.05)。结论:CPP-ACP在预防头颈部肿瘤患者放射性龋齿和牙本质敏感方面有较好疗效,值得临床应用。更多还原

【Abstract】 Objective: To compare the efficacy of casein phosphopeptide-amorphous calcium phosphate nanocomplexes(CPP-ACP) and Duraphat varnish on preventing radiation caries and dentin hypersensitivity(DH) in irradiated head and neck cancer patients. Methods: A total of 112 patients with head and neck cancer who will undergo radiotherapy were selected and randomly divided into the CPP-ACP group(experimental group) and the Duraphat varnish group(control group). A day prior to the scheduled radiotherapy, CPP-ACP containing paste had been applied once a day for 5 weeks to the teeth surface of the experimental group. Duraphat varnish was applied with the same frequency in the control group. The decay missing filling tooth(DMFT), decay missing filling surface(DMFS), and DH of two groups before radiotherapy and 12 months after radiotherapy were observed and statistically analyzed. Results: Before radiotherapy, DMFT, DMFS, and DH showed no significant differences between the groups(P>0.05). However, significant increase in DMFT, DMFS, and DH was noted in the two groups 12 months after the radiotherapy(P<0.05). A higher increase was observed in the DMFT, DMFS, and DH of the control group compared with those in the experimental group(P<0.05). Conclusion:CPP-ACP effectively reduced radiation caries and sensitivity in irradiated head and neck cancer patients and deservesclinical application.更多还原