【摘要】 目的探讨结直肠癌术后患者采用改良FOLFOX6(mFOLFOX6)方案治疗的近期疗效。方法将62例结直肠癌术后患者随机分为采用mFOLFOX6方案治疗的观察组(31例)和采用FOLFOX6方案治疗的对照组(31例),对比分析两组患者的近期疗效和不良反应。结果采用mFOLFOX6方案治疗的观察组患者的胃肠道反应、骨髓毒性、神经毒性等不良反应及在生活质量评分方面均优于对照组,差异有统计学意义(P<0.05);近期疗效与采用FOLFOX6方案治疗的对照组相似。结论 mFOLFOX6方案应用于结直肠癌术后患者不良反应较轻,患者生活质量较高,近期疗效确定。更多还原

【Abstract】 Objective To study the clinical efficacy of the chemotherapy regimen mFOLFOX6 for the patients with postoperative colorectal cancer. Methods 62 patients were randomly divided into two groups,31 cases of the observation group with chemotherapy of mFOLFOX6,and 31 cases of the control group with FOLFOX6. The toxicity and quality of life of the two groups were compared. Results The main adverse reactions were gastrointestinal adverse effects,bone marrow suppression and neurovirulence,which were more serious in the group of patients using FOLFOX6. Moreover,the observation group showed a higher quality of life. Short term efficacy of the observation group is similar to the control group. Conclusions The treatment schedule of mFOLFOX6 has less adverse effect,high quality of life and can ensure the short term curative effect.更多还原