【摘要】 目的:比较服用氨氯地平和贝尼地平治疗血管痉挛性心绞痛(VSA)的疗效。方法:研究对象为168例VSA患者,按随机数字表法将患者随机分到氨氯地平组(口服苯磺酸氨氯地平片,5 mg/片,每日1次,每次1片)和贝尼地平组(盐酸贝尼地平片,4 mg/片,bid,每次1片)。通过门诊随访记录患者症状发作次数、心电图各项指标、血压心率变化、硝酸甘油的使用量及不良反应,并对160例患者进行6年的随访。结果:2组患者的基本临床特征没有显著差异。治疗后氨氯地平组患者每周发作次数显著减少,治疗前为2.38次/周,治疗5周后为1.07次/周,治疗10周后为0.42次/周,治疗15周后为0.30次/周(与治疗前相比,P<0.05)。贝尼地平组患者发作次数治疗前为2.51次/周,治疗5周为0.93次/周,治疗10周为0.37次/周,治疗15周为0.31次/周(与治疗前相比,P<0.05)。而贝尼地平组患者无心血管事件生存率(P=0.032)和无脑血管事件生存率(P=0.015)显著高于氨氯地平组。结论:氨氯地平和贝尼地平均能有效预防VSA的发作,贝尼地平对血管痉挛性心绞痛预后良好。更多还原

【Abstract】 OBJECTIVE To compare the therapeutic efficacies of amlodipine versus benidipine sustained release tablets in the treatment of vasospastic angina( VSA). METHODS A total of 168 VSA patients were divided randomly into 2 groups of amlodipine( 5 mg,qd,po) and benidipine( 5 mg,bid,po). Their symptoms,changes of blood pressure and heart rate,dose of nitrate and adverse effects were recorded. Telephone-based follow-ups of 160 patients were successfully conducted for 6 years. RESULTS No significant inter-group difference existed in basic clinical profiles. In amlodipine group,the post-treatment number of episodes decreased significantly from 2. 38 times per week pre-treatment,1. 07 times per week post-treatment 5 weeks,0. 42 times per week post-treatment10 weeks,0. 30 times per week post-treatment 15 weeks( vs pre-treatment,P < 0. 05). In benidipine group,the post-treatment number of episodes dropped from 2. 51 times per week pre-treatment,0. 93 times per week post-treatment 5 weeks,0. 37 times per week post-treatment 10 weeks,0. 31 times per week post-treatment 15 weeks( vs pre-treatment,P < 0. 05). And,as compared with amlodipine,benidipine could significantly increase the survival without cardiovascular events( P = 0. 032) and survival without cerebral infarction( P = 0. 015) in VSA patients. CONCLUSION Amlodipine and benidipine can effectively prevent the onset of VSA. And benidipine significantly reduces the incidence of vascular infarction events.更多还原