【摘要】 目的把神经胆碱能传递下降作为一个风险因子进行研究,判断术前血清抗胆碱能活性(SAA)对于心脏术后长期认知功能障碍(POCD)的影响。方法 154例年龄大于55岁的心脏手术患者,术前应用神经心理学测试(NPT)并且测量SAA水平,术中监测S100钙结合β蛋白(S100β)浓度,术前、术中和术后记录患者特殊的特征。术后3个月时重复NPT评估POCD。结果经排除38例患者后,总共116例患者完成第二阶段的NPT,POCD发生率25.6%。与术中增高的S100β不同,术前SAA水平与POCD没有关系。结论心脏手术前SAA水平增高并不能增加术后3个月时POCD的发生率。更多还原

【Abstract】 Objective The study investigated marked deterioration in cholinergic neurotransmission as a potential risk factor and Serum anticholinergic activity(SAA) in the role of long lasting postoperative cognitive dysfunction(POCD).Method The study recruited 154 patients aged 55 years undergoing cardiac surgery.Before surgery,levels of SAA were measured and a battery of neuropsychologic tests(NPT) was applied.S100 calcium binding proteinβ(S100β)concentration was measured intraoperatively.Pre-,intra-,and postoperative patient-specific characteristics were recorded.The NPTs were repeated 3 months after hospital discharge to evaluate 3-month POCD.Result After excluding 38 patients,116 patients completed the second NPT.POCD was identified in 25.6%of patients.In contrast to intraoperatively increased S100β,preoperative SAA was not associated with POCD.Conclusion Preoperatively increased SAA did not predict POCD 3 months after cardiac surgery.更多还原