【摘要】 目的:考察CYP3A5基因多态性对汉族癫痫患者卡马西平(CBZ)稳态血药浓度及疗效的影响。方法:选取确诊为癫痫并使用CBZ治疗的患者40例,用聚合酶链反应-限制性内切片段长度多态性法检测CYP3A5基因型并分组,用高效液相色谱法测定卡马西平的稳态血药浓度,同时观察疗效和不良反应。结果:40例患者中CYP3A5*1/*1基因型(A组)27例,CYP3A5*3/*3基因型(B组)13例。两组患者CBZ剂量校正浓度分别为(12.39±4.13)和(16.54±3.89)μg/ml,标准化浓度分别为(0.21±0.08)和(0.30±0.11)μg/ml,组间比较差异均有统计学意义(P<0.05);两组患者疗效(P=0.726)和不良反应(P=0.617)比较差异均无统计学意义。结论:CYP3A5基因多态性可能影响汉族癫痫患者CBZ的稳态血药浓度,而对疗效和不良反应的影响尚不明确。更多还原

【Abstract】 OBJECTIVE:To investigate the effects of CYP3A5 gene polymorphism on steady state serum concentrations and therapeutic efficacy of carbamazepine(CBZ)in Chinese Han epileptic patients. METHODS:40 epilepsy patients receiving CBZ therapy were enrolled in the study. Steady state serum concentrations of CBZ were measured by HPLC and their CYP3A5 genotype were determined by PCR-RFLP. Therapeutic efficacy and ADR were observed. RESULTS:Among 40 patients,27 patients were CYP3A5*1/*1 genotype(group A)and 13 ones were CYP3A5*3/*3 genotype(group B). The dose-corrected serum concentration of CBZ in 2 groups were(12.39±4.13)and(16.54±3.89)μg/ml,and the normalized concentrations of CBZ were(0.21±0.08)and(0.30±0.11)μg/ml respectively;there were statistical significance(P<0.05). There was no statistical significance in therapeutic efficacy(P=0.726)and ADR(P=0.617)between 2 groups. CONCLUSIONS:The CYP3A5 gene polymorphism may affect the steady state serum concentration of CBZ in Chinese Han patients and has no significant effect on therapeutic efficacy and ADR.更多还原