【摘要】 目的探讨乳腺癌、胃癌双重癌病人的临床病理特点,为双重癌病人的研究提供临床数据参考。方法收集2001年1月至2013年6月北京大学肿瘤医院收治的乳腺癌及胃癌双重癌病人25例,其中合并卵巢癌等其他恶性肿瘤的多重癌病人6例,分析病人的临床病理特征。结果第1原发癌发病年龄30~66岁,中位45岁;以乳腺癌为主。第2原发癌35~74岁,中位54岁;以胃癌为主。胃癌病理类型以弥漫型为主,占80%;乳腺癌病理类型以浸润性导管癌为主,占88%。胃癌及乳腺癌发病间隔中位值为49(6.5~243.0)个月。结论乳腺癌及胃癌双重癌病人以发病年龄轻、发病间隔近、合并多重癌及家族史为特点,遗传学因素在发病中起重要作用。对于双重癌或多重癌,早发现、早期手术治疗才能延长生存期。更多还原

【Abstract】 Objective To investigate clinicopathological characteristics of double primary cancers of gastric cancer and breast cancer, so as to provide reference for following study of secondary primary tumor and(or) multiple primary cancers(MPC).Methods The clinicopathological data of 25 cases of double primary cancers of gastric cancer and breast cancer admitted from January 2001 to June 2013 in Beijing Cancer Hospital were analyzed. Among 25 cases, 6 cases had ovary carcinoma and(or) other malignant tumors.Results The middle onset age of the 1st primary cancer,mainly breast cancer, was 45(30-66) years old, while that of the 2nd primary cancer was 54(35-74) years old, mainly gastric cancer. The main pathology of gastric cancer was diffuse type accounting for 80%, while that of breast cancer was invasive ductal cancer accounting for 88%. The middle interval between the two cancers was 49(6.5-243.0)months.Conclusion Double primary cancers of gastric cancer and breast cancer have the characteristics of young onset age,short interval between two primary cancers and comorbidity with other primary cancers and family history, which indicates genetic susceptibility may play a role. For the treatment, early detection and early radical surgery can only prolong the survival.更多还原