【摘要】 目的观察顺式阿曲库铵联合维库溴铵用药后ED50和ED95的变化。方法将75例择期手术患者(ASAⅠ~Ⅱ级)随机分为3组:顺式阿曲库铵组、维库溴铵组和顺式阿曲库铵+维库溴铵组,每组各25例。麻醉诱导后,以单次给药法观察起效时间和T1达到最大抑制的时间,描绘3组患者的量-效曲线,求得各自的ED50和ED95值,并运用等效图法和代数法对两药相互作用进行分析。结果单用顺式阿曲库铵组、维库溴铵组ED50值分别为32.35、28.78μg/kg,ED95值分别为52.67、51.20μg/kg。联合用药时ED50值为16.81、12.17μg/kg,ED95值为23.49、22.16μg/kg,与单独用药相比,差异均有统计学意义。联合用药时ED50和ED95的合用代数值分别为0.942、0.879。结论联合使用顺式阿曲库铵和维库溴铵具有协同作用,且量-效曲线产生左移。更多还原

【Abstract】 Objective To observe the change of ED50 and ED95for the treatment with cisatracurium and vecuronium.Methods 75 cases of patients undergoing elective surgery(ASA Ⅰ to Ⅱ level) were ramdomly divided into three groups:cisatracurium group,vecuronium group and cisatracurium +vecuronium group,each group of 25 cases.The onset time and T1 maximum inhibition time were determined by the single-injection doseresponse technique after anesthesia induction.Their respective ED50 of ED95values were caculated by the depicted dose-response curve among the three groups of patients.The two medicine interaction analysis was caculated by the equivalent diagram method and algebraic method. Results ED50 was 32.35,28.78 μg/kg and ED95 was 52.67,51.20 μg/kg when patients were given single dose of atracurium or vecuronium.ED50 was 16.81,12.17 μg/kg and ED95 was 23.49,22.16 μg/kg when it combined the both two groups.Compared with other group,the differences in cisatracurium+vecuronium group were statistically significant.The combinational value of ED50 and ED95was 0.942 and 0.879,respectively. Conclusion The combination of cisatracurium and vecuronium produces synergy effect and shifts the dose-response curve to the left.更多还原