【摘要】 目的检测急性冠脉综合征(ACS)患者血清中基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)及白介素-6(IL-6)的水平及相关性并评价其临床意义。方法选取ACS患者106例分成3组,其中USAP组42例、NSTEMI组34例、STEMI组30例。用酶联免疫吸附试验(ELISA)检测所有患者MMP-2、MMP-9及IL-6水平,并用Real-Time PCR检测血清中MMP-2和MMP-9蛋白水平。结果 3组患者与对照组相比,MMP-2、MMP-9和IL-6检测水平均明显增高,其中STEMI组患者MMP-2和MMP-9比其他两组增高明显。3组患者的IL-6水平比较差异无统计学意义。ACS患者IL-6与MMP-2和MMP-9呈正相关(r=0.547、0.478,P<0.01)。结论 MMP-2、MMP-9和IL-6在ACS中高表达,可作为预测动脉硬化斑块不稳定或破裂的血清学指标,其水平有利于冠心病患者的危险分级。更多还原

【Abstract】 Objective To detect the level of MMP-2,MMP-9 and IL-6 with acute coronary syndrome(ACS),and to evaluate their clinical significance. Methods 106 cases of patients with ACS were selected and divided into USAP group(n=42),NSTEMI group(n=34)and STEMI group(n=30).The level of MMP-2,MMP-9 and IL-6 were determined by enzyme linked immunosorbent assay(ELISA).The protein level of MMP-2 and MMP-9 were determined by Real-Time PCR. Results Compared with control group,the level of MMP-2 and MMP-9 increased strongly in the other three groups respectively.Compared with STEMI group,the level of MMP-2 and MMP-9 increased strongly in the other two groups respectively.The level of IL-6 in three groups was compared,with no statistical difference.There was a positive correlation between IL-6 and MMP-2,MMP-9 respectively(r=0.547,0.478,P<0.01). Conclusion The MMP-2,MMP-9and IL-6 are highly expressed in ACS.The level of serum MMP-2,MMP-9 and IL-6 can be regarded as serum indices to judge unstable or ruptured plaque,and this is good for coronary heart disease degree.更多还原