【摘要】 目的探讨慢性肾衰竭与血浆胃泌素、胃动素的相关性。方法选择本院2013年1~12月收治的90例慢性肾衰竭患者与9例正常健康者,以肾小球滤过率分组并与血浆胃泌素、胃动素进行相关性统计分析。结果慢性肾衰竭组测定的血浆胃泌素、胃动素的指标均高于对照组;慢性肾衰竭五组的胃泌素与对照组比较差异有统计学意义(P<0.01);除GFR3、GFR4组胃动素与对照组比较差异有统计学意义(P<0.01),其余3组胃动素均差异无统计学意义(P>0.05);GFR1、GFR2、GFR3、GFR4、GFR5组及对照组的GFR与胃泌素呈正相关;GFR1、GFR2、GFR5组及对照组的GFR与胃动素呈正相关,GFR3、GFR4组的GFR与胃动素呈负相关。结论肾脏损害可能会导致胃泌素和胃动素的升高,但是并不能证明胃泌素和胃动素的升高就是肾脏损害的严重征兆,胃泌素和胃动素是消化道疾病的测定指标,可以衡量消化系统功能的损害程度,虽然它们的分泌与肾脏损害有一定程度的相关性,但不能单纯用胃泌素与胃动素的测定指标来衡量肾脏实质的损伤。更多还原

【Abstract】 Objective To investigate the correlation analysis of gastrin and motilin of plasma with chronic renal failure. Methods 90 cases of chronic renal failure patients and 9 normal healthy were selected in our hospital from January 2013 to December 2013,they were grouped by glomerular filtration rate,and the test parameters of gastrin and motilin of plasma were correlation statistical analyzed. Results The indicators of gastrin and motilin in chronic renal failure group were higher than those of the control group,the gastrin in five chronic renal failure group compared with the control group,the difference was statistically significant(P<0.01),the motilin:except GFR3,GFR4 group compared with control group, the difference was statistically significant(P<0.01),the rest of the three groups,the difference was no statistically significant(P>0.05).The GFR were positively associated with gastrin in GFR1,GFR2,GFR3,GFR4,GFR5 groups and control group. The GFR were positively associated with motilin in GFR1,GFR2,GFR5 groups and control group,but there were negatively associated with motilin in GFR3,GFR4 groups. Conclusion Kidney damage may ead to elevated gastrin and motilin,but does not prove that the rise of gastrin and motilin is kidney damage serious symptom,but does not prove that the rise of gastrin and motilin is the kidney damage serious symptom,gastrin and motilin is the determination of the digestive tract disease indexes,to measure the digestive system function damage degree,although they secrete has a certain degree of correlation with kidney damage,but you can′t simply use gastrin and motilin measurement indicators to measure renal parenchymal damage.更多还原