【摘要】 目的分析北京市1995~2011年急性弛缓性麻痹(Acute Flaccid Paralysis,AFP)病例肠道病毒(Enterovirus,EV)监测情况。方法对北京市1995~2011年AFP病例分离到的脊髓灰质炎(脊灰)病毒(Poliovirus,PV)和非脊灰(Non-polio)EV(NPEV)进行描述性分析。结果共检测478例AFP病例的967份粪便标本,在90例AFP病例的133份粪便标本中检出EV,分离率为13.75%;其中20例AFP病例的41份粪便标本检出PV(30.83%),70例AFP病例的92份粪便标本检出NPEV(69.17%)。在41份PV阳性标本中,检出PVⅡ型(Type 2)(PVⅡ)11份,PVⅢ型(Type 3)(PVⅢ)10份,分别占单型PV检出总数的40.74%和37.04%。在14例疫苗相关麻痹型脊灰(Vaccineassociated Paralytic Poliomyelitis,VAPP)病例中,PVⅡ和PVⅠ型(Type 1)(PVⅠ)+PVⅡ+PVⅢVAPP病例发病60天后随访均有不同程度的残留麻痹。2007~2008年,在NPEV阳性标本中检出7例14份粪便标本EV71型阳性,1例2份粪便标本柯萨奇病毒A组16型阳性。结论北京市1995~2011年AFP病例中,EV分布主要为NPEV,其次为PV;PVⅡ和PVⅠ+PVⅡ+PVⅢ是引起残留麻痹的主要PV型别;应深入研究EV不同血清型分布及流行规律。更多还原

【Abstract】 Objective To analysis the results of surveillance of enterovirus (EV) for the acute flaccid paralysis (AFP) in Beijing during 1995-2011. Methods Isolating and identifying poliovirus (PV) and Non-polio EV (NPEV) from AFP cases during 1995-2011 are described and analysed. Results 967 stool samples from 478 AFP cases were tested and 133 EV were isolated from 90 AFP cases,the isolation rate was 13. 75%. 41 stool samples from 20 AFP cases found PV and 92 stool samples from 70 AFP cases found NPEV. The detection rate of PV and NPEV were 30. 83% and 69. 17% respectively. 11 PV Type 2 (PV Ⅱ) and 10 PV Type 3 (PV Ⅲ) were isolated from 41 samples of PV positive stool samples which account for 40. 74% and 37. 04% respectively of detection number of the PV Ⅰ + PV Ⅱ + PV Ⅲ; In 14 cases vaccine associated paralytic poliomyelitis (VAPP),PV Ⅱ and PV Ⅰ + PV Ⅱ + PV Ⅲ cases remain disability after sixty days paralysis; Fourteen positive samples from seven AFP cases and two samples from one AFP cases were isolated type 16,group A of coxsackie virus (CV) EV 71 during 2007-2008. Conclusions The NPEV was the main part of EV in type16,group A (CVA16) from 1995-2011,and second was PV. Disability after 60 days Paralysis was caused mainly by PV Ⅱ and PV Ⅰ + PV Ⅱ + PV Ⅲ serotypes. The prevalent and the distribution of different serotypes of EV should be studied continuously.更多还原