【摘要】 目的探讨肺功能Ⅱ级及以上老年稳定期慢性阻塞性肺疾病(简称慢阻肺)患者血清IL-6、TNF-α、CRP的水平及与肺功能的相关性。方法选取2012年11月至2014年3月到甘肃省人民医院就诊的门诊或住院的肺功能Ⅱ级及以上稳定期的老年慢阻肺患者60例为慢阻肺组,同期体检的35例健康老年人为对照组,检测血清IL-6、TNF-α、CRP水平,并对三者与慢阻肺患者肺功能的相关性进行探讨。应用SPSS17.0软件进行统计学分析。结果老年稳定期慢阻肺组血清IL-6、TNF-α、CRP水平明显高于健康对照组,差异有统计学意义(P<0.01)。在慢阻肺Ⅱ级、Ⅲ级和Ⅳ级患者中,血清IL-6、TNF-α、CRP水平逐渐升高(P<0.01),肺功能FEV1%pred、FEV1/FVC逐渐降低(P<0.05);血清IL-6、TNF-α、CRP水平与患者肺功能呈负相关(P<0.05)。结论老年稳定期慢阻肺患者存在气道炎症,这种气道炎症可能是导致慢阻肺患者肺功能进行性下降的原因。更多还原

【Abstract】 Objective To explore the relationship of levels of serum interleukin-6( IL-6),tumor necrosis factor-α( TNF-α) and C-reactive protein( CRP) with lung function in elderly patients with stable COPD and whose pulmonary function classification was level Ⅱ or above. Methods Sixty elderly patients with stable COPD and with the pulmonary function classification of level Ⅱ or above and 35 age-matched healthy subjects in the Gansu Provincial Hospital from November 2012 to March in 2014 were recruited in the study. Serum IL-6,TNF-α and CRP levels were detected by electro-chemiluminescence immunoassay( ECLI),enzyme-linked immunosorbent assay and immunoturbidimetric assay,respectively. And their relationships with lung function were explored by Spearman correlation analysis. Results The levels of serum IL-6[( 33. 0 ±15. 1) mg /L vs.( 15. 9 ± 8. 7) mg /L],TNF-α [( 53. 8 ± 20. 1) pg /mL vs.( 22. 2 ± 8. 0) pg /mL] and CRP[( 8.7 ±3.9) mg/L vs.( 5.8 ±2.3) mg/L]were significantly higher in the stable COPD patients than those in the healthy controls( P < 0. 01). With the increase of COPD severity grade,the levels of serum IL-6,TNF-αand CRP increased gradually,and the lung function of FEV1% pred and FEV1/FVC decreased gradually( P <0. 05). The levels of serum IL-6,TNF-α and CRP were negatively correlated with lung function( P < 0. 05).Conclusions There is airway inflammation in elderly patients with stable COPD. Airway inflammation may be the reason of the decline of pulmonary function in patients with stable COPD.更多还原