【摘要】 目的探讨肱动脉血压正常者中测量中心动脉收缩压(cSBP)的意义。方法 2010年4月至6月期间对北京市石景山区首钢地区常住居民进行调查,从中筛选肱动脉血压正常者823人(男297人,女526人),年龄22~86(55.8±11.7)岁。根据年龄分为5个年龄组:<40(n=60)、40~<50(n=170)、50~<60(n=350)、60~<70(n=133)和≥70岁组(n=110)。采用科林HEM-9000AI脉波检测装置检测无创cSBP,测量生化指标、颈动脉内膜中层厚度(IMT)、臂踝脉搏波传导速度(baPWV)和踝臂血压指数(ABI)等指标。结果 cSBP≥140mm Hg的受试者占12.5%。女性40~<50、50~<60、60~<70和≥70岁组,男性40~<50、50~<60和≥70岁组人群中,cSBP≥140mm Hg者的baPWV高于cSBP<140mm Hg者(均P<0.05)。≥70岁组cSBP≥140mm Hg者最大IMT高于cSBP<140mm Hg者(P<0.05)。多元线性回归分析显示,腰臀比、baPWV、空腹血糖是男性cSBP的独立影响因素(β值分别为0.13,0.35,-0.13,均P<0.05);baPWV是女性cSBP的独立影响因素(β=0.47,P<0.01)。结论 >40岁的肱动脉血压正常者的cSBP≥140mm Hg时,血管功能损害加重。更多还原

【Abstract】 Objective To assess the significance of measuring central aortic systolic blood pressure(cSBP)among normotensive crowds. Methods From April to June in 2010,a cross-sectional study was conducted in the inhabitants of Shijingshan District,Beijing. Eight hundred and twenty-tree participants with normal blood pressure and aged 55.8±11.7(range:22-86)years were included in this study,including 297 males and 526 females. All participants were divided into five groups by age<40(n=60),40-<50(n=170),50-<60(n=350),60-<70(n=133)and ≥70years old(n=110). The cSBP,biochemical parameters,intima-media thickness(IMT),brachialankle pulse wave velocity(baPWV),and ankle-brachial index(ABI)were measued simultaneously. Results12.5% of study participants had elevated cSBP(cSBP≥140mm Hg). The baPWV in participants with elevated cSBP(cSBP≥140mm Hg)was consistently higher than those with lowered cSBP(cSBP<140mm Hg)in female subgroups of aged 40-<50,50-<60,60-<70and ≥70years and in male subgroups of aged 40-<50,50-<60,and≥70years(P<0.05 for all). In participants aged≥70years,the maximum IMT was higher in participants with elevated cSBP than those with lowered cSBP(P<0.05). Multivariable regression analysis indicated that waist-hip ratio,baPWV and fasting glucose were the independent influential factors for cSBP in male participants(β=0.13,0.35,-0.13,all P <0.05),and baPWV in female participants(β=0.47,P <0.01).Conclusion The normotensive crowds with cSBP≥140mm Hg aged over 40 may be accompanied by the higher degree of the functional lesion in artery.更多还原