Objective To investigate the effects of resveratrol( RES) on bone mineral density( BMD),serum contents of nitrogen monoxid( NO) and nitricoxide synthase( NOS) in ovariectomized female rats. Methods Forty-eight Sprague-Dawley female rats were randomly divided into 6 groups: sham operated group,ovariectomized( OVX) group, OVX supplemented with 0. 03 mg / kg diethylstilbestrol group( DES),and OVX groups supplemented with RES at dosage of 5,15 and 45 mg / kg,respectively. The duration of exposure was 90 days. T...
【基金】
广东省科技计划项目(2011B061300032)
【更新日期】
2014-07-01
【分类号】
R285.5
【正文快照】
绝经后骨质疏松(postmenopausal osteoporosis,PMOP)是中老年女性的常见骨病,主要表现为骨密度(bone mineral density,BMD)下降,骨微结构破坏和骨折危险性增加。随着人类平均寿命延长及社会的老龄化,绝经后骨质疏松导致的疾病负担也更加严重,有报道显示中国北方绝经后女性的骨?