【摘要】 目的:评价不同年龄段宫颈病变患者检测人乳头状瘤病毒(HPV)感染状况的临床意义。方法:对妇产科门诊及住院宫颈病变患者174例作宫颈组织病理检查,采用PCR-反向点杂交法检测宫颈病变患者感染的HPV不同亚型。结果:174例HPV感染者分为高危型HPV及多重感染153例,以HPV 16、52、58型最常见。高危型与低危型HPV混合感染3例,低危型HPV及多重感染18例,以6、11、43型多见,中国特有的高危型CP8304共4例。高危型HPV及多重感染与低危型HPV及多重感染组相比宫颈病变程度的差异均有统计学意义(P<0.05),患宫颈癌风险增加,尤其是31~50岁的患者。结论:HPV检测可用于临床筛查及病情判断,对感染HPV特别是高危型HPV应高度重视,做到早诊断、早阻断、及时、全程治疗,定期复查追踪预防宫颈癌的发生。更多还原

【Abstract】 Objective: To evaluate the clinical significance of human papillomavirus( HPV) infection detection in patients with cervical lesions of different ages. Methods: Cervical pathological examination was conducted among 174 patients with cervical lesions in gynecological outpatient department and inpatient department of the hospital,PCR- reverse dot blotting was used to detect the subtypes of HPV infection. Results: The patients were divided into high risk HPV infection and multiple HPV infection group( 153 patients,HPV 16,52,58 were the most common subtypes),mixed infection of high risk HPV and low risk HPV group( 3 patients),low risk HPV infection and multiple HPV infection group( 18 patients,HPV 6,11,43 were the most common subtypes); 4 patients were found with high risk CP8304which was specific in China; there was statistically significant difference in the degree of cervical lesions between patients with high risk HPV infection and multiple HPV infection and patients with low risk HPV infection and multiple HPV infection( P < 0. 05),the risk of cervical cancer increased,especially in patients aged 31- 50 years old. Conclusion: HPV detection can be used for clinical screening and judgment,more attention should be paid to HPV infection especially high risk HPV infection; early diagnosis,early treatment,timely and overall treatment,regular reexamination and follow- up should be achieved to prevent the occurrence of cervical cancer.更多还原