【摘要】 目的:探讨HIV感染相关性宫颈癌的发病率和一般临床特点。方法:收集2008年4月~2012年3月间住院治疗的全部HIV阳性宫颈癌患者(A组)的临床资料,同时收集2010年3月间连续入院同等数量HIV阴性宫颈癌患者(B组)的临床资料,将两组资料进行对比。结果:两组患者在发病年龄(P=0.038)、T淋巴细胞亚群构成(P=0.000)及全身多发淋巴结肿大发生率(P=0.003)方面均有统计学差异。结论:HIV阳性宫颈癌患者较HIV阴性患者发病更早、T淋巴细胞免疫功能下降、全身多发淋巴结肿大发生率显著增加,提示HIV感染导致免疫功能低下,在HIV阳性宫颈癌发生过程中发挥了重要作用。更多还原

【Abstract】 Objective: To explore the incidence rate and general clinical characteristics of human immunodeficiency virus( HIV)infection- related cervical cancer. Methods: The clinical data of patients with HIV infection- related cervical cancer( group A) treated in the hospital from April 2008 to March 2012 were collected; meanwhile,the clinical data of patients with HIV- negative cervical cancer( group B) treated in the hospital in March 2010 were collected,then the data in the two groups were compared. Results: There were statistically significant differences in onset age( P = 0. 038),proportion of T lymphocyte subsets( P = 0. 000) and incidence rate of total body multiple lymphadenectasis( P = 0. 003) between the two groups. Conclusion: The patients with HIV infection- related cervical cancer is younger than the patients with HIV- negative cervical cancer,the immunologic function of T lymphocytes decreases,the incidence rate of total body multiple lymphadenectasis increases significantly,which indicate that HIV infection can induce impaired immunity and play an important role in occurrence of HIV infection- related cervical cancer.更多还原