【摘要】 目的:探讨早产儿血清降钙素原(PCT)、白细胞介素-6(IL-6)水平变化对早产儿细菌感染性疾病及解脲支原体(UU)感染的诊断价值。方法:选择在该院住院诊治的早产儿共110例,按出院诊断分为细菌感染组和对照组(非细菌感染组)各40例,UU感染组30例,所有新生儿于生后6~12 h采血检测PCT、IL-6、C反应蛋白(CRP)。结果:细菌感染组血清PCT、IL-6、CRP水平明显升高,与UU感染组比较差异有统计学意义,与对照组比较差异有统计学意义(P<0.01);而UU感染组血清PCT、IL-6水平明显升高,与对照组比较差异有统计学意义(P<0.01)。与CRP比较,PCT、IL-6在诊断细菌感染灵敏度方面优于CRP,而特异度不如CRP。PCT、IL-6在诊断UU感染方面灵敏度及特异度都不高。结论:PCT、IL-6有助于早产儿全身性细菌感染的早期诊断,具有较高的敏感性。有助于指导临床及时合理应用抗生素。更多还原

【Abstract】 Objective: To explore the values of changes of serum procalcitonin(PCT) and interleukin-6(IL-6) levels in diagnosis of bacterial infectious diseases and Ureaplasma urealyticum(UU) infection in premature infants. Methods: A total of 110 premature infants diagnosed and treated in the hospital were selected,and then they were divided into bacterial infection group(40 infants),control group(40 infants) and UU infection group(30 infants) according to discharge diagnosis; the levels of PCT,IL- 6,C- reactive protein(CRP) were detected at 6-12 hours after birth. Results: The serum levels of PCT,IL-6,and CRP in bacterial infection group increased significantly,compared with UU infection group and control group,there was statistically significant difference(P < 0. 01); the serum levels of PCT and IL- 6 in UU infection group increased significantly,compared with control group,there was statistically significant difference(P <0. 01); the sensitivities of PCT and IL 6 were higher than that of CRP in the diagnosis of bacterial infection,but the specificities of PCT and IL 6 were lower than that of CRP; the sensitivity and specificity of IL 6 in the diagnosis of UU infection were not high. Conclusion: PCT and IL- 6 are helpful to early diagnose systemic bacterial infection of preterm infants with high sensitivity,which contributes to directing timely and reasonable application of antibiotics in clinic.更多还原