【摘要】 目的:探讨Klotho基因-395A/G多态性和子痫前期的发病及其严重程度的相关性。方法:采用等位基因特异性多聚酶链反应(AS-PCR)技术以182例患有子痫前期的孕妇(其中轻度子痫前期98例,重度子痫前期84例)和200例在郑州大学第二附属医院进行产前检查并分娩的正常孕妇为研究对象,检测Klotho基因G-395A多态性分布的基因型。结果:A等位基因型频率在子痫前期组高于对照组,差异有统计学意义(P<0.05),A等位基因型频率在重度子痫前期组高于轻度子痫前期组,差异有统计学意义(P<0.05)。结论:Klotho基因多态性的A等位基因可能是中原地区汉族妇女发生子痫前期的遗传危险因素,并与病情严重程度有关。更多还原

【Abstract】 Objective: To explore the correlation between 395A/G polymorphism of Klotho gene and onset,severity of preeclampsia. Methods: AS- PCR rechnique was used to detect the genotypes of 395A / G polymorphism distribution of Klotho gene in 182 pregnant women with preeclampsia( including 98 pregnant women with mild preeclampsia and 84 pregnant women with severe preeclampsia) and 200 normotensive pregnant women who received prenatal examination and gave birth to their babies in the hospital. Results: The frequency of A allele in preeclampsia group was statistically significantly higher than that in control group( P < 0. 05); and the frequency of A allele in severe preeclampsia group was statistically significantly higher than that in mild preeclampsia group( P < 0. 05). Conclusion: A allele of 395A / G polymorphism of Klotho gene may be one of genetic risk factors of preeclampsia for Chinese women in central China and it may also be associated with its degree of severity.更多还原