【摘要】 目的:探究新生儿B组链球菌(GBS)感染导致的化脓性脑膜炎的临床药物干预的有效途径。方法:该院产后新生儿经B组链球菌免疫学抗原检查阳性并经脑脊液检查确诊的化脓性脑膜炎患者60例,经伦理审查通过,并与患者家属签署知情同意书,将患儿等量随机分为联合治疗组30例(头孢曲松钠联合氨苄西林治疗)和对照组30例(单纯氨苄西林治疗)。两组均辅助地塞米松及丙种免疫球蛋白基础治疗,比较两组患者临床症状的缓解及其不良事件的发生率。结果:脑膜炎患儿早期药物预防联合治疗组的临床症状缓解的平均水平明显优于对照组,差异具有统计学意义(P<0.05);在随访期合并并发症发生率联合治疗组(0)低于对照组(13.3%),差异具有统计学意义(P<0.05)。结论:联合治疗组治疗新生儿B组链球菌感染所致化脓性脑膜炎的效果较好,为临床治疗提供一定程度的支持。更多还原

【Abstract】 Objective: To explore effective ways of clinical drug intervention purulent meningitis caused by neonatal group B streptpcoccal infection encephalitis. Methods: 60 cases of the newborns were chosen,who were tested positive after group B Streptpcoccus immunological antigen test and diagnosed early purulent meningitis by cerebrospinal fluid examination. Through the ethical review,and the informed consent were signed with the family members of patients. The children patients were randomly divided into the combined adjuvant therapy group with 30 cases( ceftriaxone and ampicillin) and the control group with 30 cases( simple ampicinin treatment group). The two groups were assisted with Dexamethasone and IVIG,and the incidence of adverse events and clinical symptoms in the two groups were compared. Results: Early meningitis with early preventive medicine,the average clinical symptom relief of the combined adjuvant therapy group were better than those of the control group,there were statistical significance( P < 0. 05). During the follow-up period,the incidence complication rate of the combined adjuvant therapy group was significantly lower than that of the control group by 13. 3%,there was statistical significance( P = 0. 04 < 0. 05). Conclusion: It has good curative effects on purulent meningitis caused by neonatal group B streptpcoccal infection encephalitis in the combined adjuvant therapy group,providing considerable support for clinical treatment.更多还原