【摘要】 目的探讨养血清脑颗粒对脑梗死患者颈动脉内-中膜厚度以及动脉粥样硬化斑块大小的影响,以及养血清脑颗粒对脑梗死患者的二级预防作用机制。方法将100例脑梗死患者随机分成两组。第1组为对照组,给予常规抗血小板聚集,改善循环,营养神经等对症治疗,住院治疗2 w后,只给予口服拜阿司匹林6 m。第2组为治疗组,除给予上述常规治疗外,同时给予养血清脑颗粒4 g,每日3次口服,住院治疗2 w后,继续口服拜阿司匹林加养血清脑颗粒6 m。6 m后测量患者颈动脉内-中膜厚度及动脉粥样硬化斑块大小以及检测血常规、凝血常规、血脂、血糖、血液粘度。对两组患者数据进行统计学分析。结果对照组50例患者6 m后随诊复查,颈部彩超显示斑块面积缩小7例,无明显改变者20例,斑块面积增大者23例。治疗组50例患者颈部彩超显示斑块面积缩小25例,无明显改变者16例,斑块面积增大者9例。治疗组患者,颈动脉内膜的动脉粥样硬化斑块面积治疗前后比较均有明显缩小,有显著性差异(P<0.01)。而对照组患者治疗前后斑块面积无明显改变,无显著性差异(P>0.05)。结论养血清脑颗粒可改善脑梗死患者的颈动脉内-中膜厚度,对脑梗死患者的二级预防有一定价值。更多还原

【Abstract】 Objective To investigate the effect of cerebralcare granule on cerebral infarction patients with carotid intima-media thickness and atherosclerotic plaque size,as well as the mechanism of cerebralcare granule in the two grade prevention of cerebral infarction. Methods 100 cases of cerebral infarction were randomly divided into two groups. The first group was control group,treated with conventional anti-platelet aggregation,circulation improvement and nerve nutrition drugs. After 2 weeks hospitalization,patients were given oral aspirin for 6 months. The second group was treatment group, in addition to the conventional treatment,cerebralcare granule were given orally,4 grams 3 times a day. 2 weeks after hospital treatment,oral administration of aspirin plus cerebralcare Granule were continued for 6 months. Carotid artery intimamedia thickness and the size of atherosclerotic plaque were measured after 6 months,and blood coagulation,blood lipids, blood glucose,blood viscosity were detected. Statistical analysis was conducted on the data of two groups of patients. Results In control group,after 6 months of follow-up review,plaque area reduced in 7 cases of 50 patients by carotid ultrasonography examination,no change in 20 cases,patch area increased in 23 cases. In treatment group,plaque area of 25 cases in 50 patients reduced by neck ultrasound examination,no change in 16 cases,patch area increased in 9 cases. In treatment group,the area of atherosclerotic plaque of carotid artery intima compared before and after treatment were significantly reduced,there was significant difference( P < 0. 01). While the control group before and after treatment in patients with plaque area had no obvious change,and no significant difference( P > 0. 05). Conclusions Cerebralcare granule can improve cerebral infarction in patients with carotid artery intima-media thickness,two grade prevention has certain value.更多还原