【摘要】 结核病是一种与营养不良有关的传染性疾病。营养不良可影响肝脏合成血清白蛋白功能,从而诱发或加重药物性肝功能损伤(简称“肝损伤”)。抗结核药物可引起药物性肝损伤,在营养不良的状况下,肝血流灌注障碍,肝血流量减少,使药物清除率下降,加重药物性肝损伤。因此,在结核病合并营养不良的患者治疗过程中,应该在积极抗结核治疗的同时加强营养支持治疗;改善结核病患者的营养状况,是减少抗结核药物性肝损伤,使抗结核治疗顺利进行的重要保证。更多还原

【Abstract】 Tuberculosis is a contagious disease related to malnutrition.Malnutrition can affect synthesis of serum albumin in liver,and also induce or exacerbate drug-induced liver injury.Under the conditions of malnutrition,drug-induced liver injury caused by anti-tuberculosis drugs may lead to hepatic perfusion disorders,reduce the hepatic blood flow and the clearance of drugs,and exacerbate this disease.Therefore,during the treatment for patients with tuberculosis combined with malnutrition,anti-tuberculosis treatment and improvement the nutritional status,should be implemented actively.Improvement of the nutritional status in patients with tuberculosis is very important to reduce drug-induced liver injury and to guarantee anti-tuberculosis treatment performed smoothly.更多还原