【摘要】 目的探讨淋巴结内栅栏状肌纤维母细胞瘤的临床病理特点。方法观察1例腹股沟淋巴结内栅栏状肌纤维母细胞瘤的组织学及免疫表型,并复习相关文献。结果患者女性,51岁。左侧腹股沟无痛性包块4个月。镜下肿瘤由分化成熟的梭形瘤细胞呈栅栏状排列,伴石棉样纤维及肿瘤实质出血、裂隙状血管腔形成。免疫组化:瘤细胞vimentin、SMA、actin和cyclin D1(+),desmin、S-100、Syn、CD117、CD99、HMB45、melan-A、bcl-2、Factor-Ⅷ、CD34、EMA和AE1/AE3(-),Ki-67增殖指数2%。结论淋巴结内栅栏状肌纤维母细胞瘤是原发于淋巴结内罕见的良性间叶性肿瘤,结合影像学、病理学特征及免疫组化可确诊,预后良好。更多还原

【Abstract】 Objective To explore the clinicopathologic features of intranodal palisaded myofiborblastoma( IPM). Methods The histological and immunological phenotype in a case of IPM was studied and the related literatures were reviewed. Results A 51-year-old woman presented with 4 months history of a painless nodule in the left inguinal region. Microscopically,the lesion was composed of bland looking spindle cells with area of nuclear palisading,amianthoid fibres and areas of fresh as well as old hemorrhages. The spindle cells showed positive staining of vimentin,SMA and actin, cyclin D1,but negative for desmin,S-100,Syn,CD117,CD99,HMB45,melan-A,bcl-2,factor-Ⅷ,CD34,EMA and AE1 / AE3,and low expression of Ki-67 was noted. Conclusion IPM,which possesses a good prognosis,is a rare benign mesenchymal tumor in lymph nodes. It can be diagnosed through imaging, clinicopathologic features and immunological phenotype.更多还原