【摘要】 目的研究产自内蒙古杭锦旗的乌拉尔甘草Glycyrrhiza uralensis根中的黄酮类成分。方法采用硅胶、聚酰胺、MCI、ODS、Sephadex LH-20、RP-HPLC等色谱方法分离纯化,根据理化性质和波谱数据进行结构鉴定。结果从乌拉尔甘草根95%、70%乙醇提取物中分离得到19个化合物,分别鉴定为3-甲基山柰酚(1)、染料木素(2)、柚皮素(3)、甘草异黄酮甲(4)、甘草利酮(5)、异芒柄花素(6)、半甘草异黄酮B(7)、3′-异戊烯基染料木素(8)、黄羽扇豆魏特酮(9)、甘草黄酮醇(10)、黄宝石羽扇豆素(11)、甘草异黄酮乙(12)、异甘草黄酮醇(13)、甘草宁H(14)、粗毛甘草素A(15)、甘草西定(16)、粗毛甘草素D(17)、香豌豆酚(18)、7-甲基羽扇豆异黄酮(19)。结论化合物1、6、8、18、19为首次从甘草属植物中分离得到,化合物2~4、12、14、15为首次从该种植物中分离得到。更多还原

【Abstract】 Objective To investigate the flavonoids in the roots of Glycyrrhiza uralensis from Hangjinqi, Inner Mongolia. Methods The 95% and 70% ethanol extracts from the roots of G. uralensis were separated and purified by column chromatography over silica gel, polyamide, MCI, ODS, Sephadex LH-20, and RP-HPLC. Their chemical structures were identified on the basis of physicochemical characteristics and spectral analyses. Results Nineteen compounds were isolated and identified as 3-methylkaempherol(1), genistein(2), naringenin(3), licoisoflavone A(4), licoricone(5), isoformononetin(6), semilicoisoflavone B(7), 3′-isoprenylgenistein(8), lupiwighteone(9), licoflavonol(10), topazolin(11), licoisoflavone B(12), isolicoflavonol(13), gancaonin H(14), glyasperin A(15), licoricidin(16), glyasperin D(17), orobol(18), and 7-methyl-luteone(19). Conclusion Compounds 1, 6, 8, 18, and 19 are isolated from the genus Glycyrrhiza Linn. and compounds 2—4, 12, 14, and 15 are isolated from this plant for the first time.更多还原