【摘要】 目的探讨抗结核药致药物性肝损害(DILI)的临床特点。方法回顾分析我科129例肺结核患者在抗结核治疗过程中发生DILI的临床资料。结果高龄、嗜酒、肝炎病毒携带者或有肝病史、抗结核药物治疗的1~3周、血行播散型肺结核更易发生药物性肝损害。结论对抗结核药致DILI的早期诊断和及时合理治疗,以保证患者能够顺利完成化疗。更多还原

【Abstract】 Objective to investigate the drug-induced liver damage caused by anti- tuberculosis drugs(DILI) clinical characteristics. Methods Retrospective analysis clinical data of 129 cases of pulmonary tuberculosis patients in our department with the occurrence of DILI in anti tuberculosis treatment process. Results the elderly,drinking,hepatitis B virus carriers or a history of liver disease,anti-tuberculosis drug treatment of line 1~3 weeks,disseminated blood type lung tuberculosis more susceptible to drug-induced liver injury.Conclusions early diagnosis of DILI induced by anti- tuberculosis drugs and proper treatment,to ensure that patients can be successfully completed chemotherapy.更多还原