【摘要】 目的采用HPLC测定考察头孢呋辛酯片含量及有关物质。方法流动相A:0.2 mol/L磷酸二氢铵溶液,流动相B:甲醇,A∶B=62∶38,流速:1 mL/min;柱温:28℃;检测波长:278 nm;进样量:20μL。结果回归方程Y=600.4X+2.781,r=0.9999,0.048288~0.6036μg/mL线性关系良好。结论所用方法可用于孢呋辛酯片的测定及有关物质的检查。更多还原

【Abstract】 Objective To establish a method for determination of cefuroxime axetil and its related substances. Methods The analysis was performed by HPLC, a mobile phase of 0.2 mol/L dihydrogen phosphate amine solution-methanol(62∶38) with a flow rate at 1mL/min. The UV detective wavelength was 278 nm. Results The calibration curves showed good linear response ranged from 0.048288 to 0.6036 μg/mL for cefuroxime axetil tablets and its related substances.Conclusion The method is simple, accurate, specific, and can be used for quality control of cefuroxime axetil and examination of its related substances.更多还原