【摘要】 以(S)-苯乙胺和丙烯酸甲酯为原料,方便地合成了一对非对映的氮杂醇手性配体,研究了它们在锌催化的不对称的Henry反应中不对称催化效果,β-硝醇的加成产物达到中等的催化效果(高达64%的ee值)。同时探讨了可能的催化机理。更多还原

【Abstract】 A pair of diastereoisomeric aziridino alcohols which could be readily prepared from the reaction between( S)-α-methylbenzyl amine and methyl acrylate has been used as chiral ligands in zinc-catalyzed enantioselective Henry reaction between nitromethane and arylaldehydes. A moderate enantioselectivity of β-nitroalcohol,up to 64% ee value,could be achieved in this catalytic reaction. The possible transition states of the reaction were proposed.更多还原