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氯吡格雷与阿司匹林联合阿托伐他汀治疗短暂性脑缺血发作疗效研究

Clinical Efficacy of Clopidogrel and Aspirin Combined with Atorvastatin in Treating Transient Ischemic Attack

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【作者】 郭文波燕子安刘文阁刘希云韩春娥

【Author】 Guo Wenbo;Yan Zian;Liu Wenge;Liu Xiyun;Han Chune;Changli County People’ s Hospital;

【机构】 河北省昌黎县人民医院

【摘要】 目的探讨氯吡格雷、阿司匹林联合阿托伐他汀治疗短暂性脑缺血发作的临床疗效。方法选取2009年6月至2013年6月住院治疗的短暂性脑缺血发作患者150例,随机分为对照组和观察组,各75例,对照组采用阿司匹林+氯吡格雷治疗,观察组在对照组用药基础上联合阿托伐他汀治疗。结果观察组总有效率为92.00%,明显高于对照组的73.33%(P<0.05),治疗期间未出现明显的出血倾向及横纹肌溶解等严重并发症。结论氯吡格雷、阿司匹林联合阿托伐他汀治疗短暂性脑缺血发作的效果明显优于氯吡格雷、阿司匹林,且方法简便,安全可靠。

【Abstract】 Objective To investigate the clinical effect of clopidogrel and aspirin combined with atorvastatin in treating transient ischemic attack. Methods 150 inpatients with transient ischemic attack admitted to our hospital from June 2009 to June 2013 were selected and randomly divided into the control group and the observation group,75 cases in each group. The control group was treated by aspirin plus clopidogrel,while on this basis the observation group was added atorvastatin. Results The total effective rate was 92. 00% in the observation group which was significantly higher than 73. 33% in the control group( P < 0. 05). No serious complications of bleeding tendency and rhabdomyolysis occurred during treatment in the two groups. Conclusion Clopidogrel and aspirin combined with atorvastatin is superior to clopidogrel and aspirin group in the effect for treating transient ischemic attack,moreover this method is simple,convenient,safe and reliable.

【基金】 河北省秦皇岛市科研基金项目,项目编号:201101A402
  • 【文献出处】 中国药业 ,China Pharmaceuticals , 编辑部邮箱 ,2014年22期
  • 【分类号】R743.3
  • 【被引频次】22
  • 【下载频次】96
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