【摘要】 目的探讨急性ST段抬高型心肌梗死(STEMI)患者急诊经皮冠状动脉介入治疗(PCI)后,其入院时即刻外周血白细胞(WBC)计数与住院期间肌钙蛋白I(cTnI)峰值的相关性。方法收集2011年1月至2012年12月因急性STEMI就诊于抚顺市中心医院且行急诊PCI治疗的患者86例,依据入院即刻WBC计数水平分为WBC正常组(WBC≤10×109/L)和WBC升高组(WBC>10×109/L)。比较两组患者的临床特征,分析WBC与cTnI峰值的相关性。结果与WBC正常组相比较,WBC升高组患者的cTnI峰值及C反应蛋白水平显著升高、低密度脂蛋白胆固醇水平下降(P<0.05);多元逐步回归分析结果显示,WBC与cTnI峰值及CRP水平呈正相关(P<0.05)。结论急性STEMI行急诊PCI术的患者,入院时即刻WBC水平与cTnI峰值密切相关,WBC作为炎症指标可以间接反映急性STEMI患者心肌梗死面积的大小。更多还原

【Abstract】 Objective To investigate the relationship between peripheral white blood cell( WBC) count and cardiac troponin I( cTnI) in acute ST-elevation myocardial infarction( STEMI) patients with successful primary percutaneous coronary intervention( PCI). Methods A total of 86 patients admitted to Fushun Central Hospital for primary PCI for acute STEMI from Jan. 2001 to Dec. 2012 were categorized into two groups according to the levels of WBC after Emergency admission: WBC normal group( WBC≤10 × 109/ L), WBC elevated group( WBC > 10 × 109/ L). Clinical characteristics were compared between the two groups, the levels of WBC and cTnI peak were measured in patients. Results Compared with WBC normal group, cTnI peak and CRP levels were significantly elevated,while LDL-C levels were decreased in WBC elevated group( P < 0. 05). Multiple stepwise regression analysis showed: WBC counts was positively correlated with CRP levels and cTnI peak( P < 0. 05). Conclusion WBC level is closely associated with cTnI peak in acute ST-elevation myocardial infarction patients with successful PCI,and WBC as inflammatory markers may indirectly reflect myocardial infarct size in patients with acute STEMI.更多还原