【摘要】 局灶节段性肾小球硬化(FSGS)由多种病因引起,临床主要以大量蛋白尿及肾病综合征为主要表现,病理表现为肾小球局灶节段性硬化。患者主要表现为蛋白尿,并逐步进展为慢性肾功能不全。FSGS早期已存在足突广泛融合、凋亡、脱落及损伤,表明足细胞是其发生、发展的主要目标细胞。该文将近年来关于足细胞与FSGS的研究进展予以综述。更多还原

【Abstract】 Focal segmental glomerular sclerosis( FSGS) is caused by a variety of factors,with massive proteinuria and nephrotic syndrome as the main clinical manifestation,and focal segmental glomerulosclerosis as the main pathological manifestations. The main clinical manifestation is proteinuria,which gradually progresses to chronic renal insufficiency. The fusion of foot processes,apoptosis,fall-off and damage extensively exist in the early stage of FSGS,showing that podocytes are the main target cells of the occurrence and development. Here is to make a review of the research progress in podocytes and FSGS in recent years.更多还原