【摘要】 通过研究高通量血液透析(HFHD)和血液透析滤过(OL-HDF)两种血液净化模式对尿毒症患者血清白介素-1β(IL-1β)、超敏C反应蛋白(hs-CRP)、降钙素原(PCT)、钙(Ca)、磷(P)、胎球蛋白A(Fetuin-A)水平的影响,旨在求其相关性。按不同血液净化模式,将维持性血液透析(MHD)患者随机分为HFHD组(A组)30例,OL-HDF组(B组)30例,健康对照组(C组)16例,通过测定A组、B组、C组透析前、A组、B组透析6个月后各项化验指标,经过统计学分析比对发现A组、B组血清Fetuin-A与IL-1β、hs-CRP、P、Ca×P呈负相关。本研究证明,MHD患者存在微炎症状态,其钙化抑制因子Fetuin-A较正常人明显降低,长期OL-HDF治疗(治疗大于6个月)对于改善MHD患者微炎症状态及升高钙化抑制因子Fetuin-A效果均明显优于HFHD。更多还原

【Abstract】 Correlation of HFHD and OL-HDF was obtained by studying effects of HFHD and OL-HDF on IL-1β,hs-CRP,PCT,Ca,P,and Fetuin-A levels of patients with uremia.According to different blood purification modes,MHD patients were randomly divided into three groups,namely group A including 30 cases of HFHD,group B including 30 cases of OLHDF and control group C with 16 healthy cases.By determination of various assay indexes of group A and B before and after 6-month dialysis and group C,it was found that Fetuin-A has a negative correlation with IL-1β,hs-CRP,P and Ca×P respectively by statistical analysis and comparison.This research showed that a micro-inflammatory state existed in MHD patients and their calcification inhibitors,Fetuin-A,are significantly reduced compared with that of normal people.The effect of a long-term OL-HDF treatment(for more than 6months)is much better than a HFHD treatment in aspects of improving the micro-inflammatory state and increasing the calcification inhibitors,Fetuin-A of MHD patients.更多还原