【摘要】 应激是机体受到各种内外环境因素刺激时的适应性反应,当反应持续时间过久或长期处于激活状态,则会对机体产生不良影响。目前认为,老化与糖皮质激素的过量分泌所致大脑相关区域的损伤相关,这些区域不仅参与认知与情绪,而且与下丘脑-垂体-肾上腺轴控制的其他活动相关。除此之外,皮质醇基础水平的差异性、皮质醇在脑内的可用性、糖皮质激素受体的失衡及大脑本身的易损性、回弹性等都是应激影响脑老化的参与因素。本文将对应激所致正常或非正常老化过程的相关影响机制与学说进行综述。更多还原

【Abstract】 Stress is an adaptive response when suffering from various internal and external environmental stimulation factors.However,if this response sustains for more time than necessary or if the body is activated chronically,harmful effects will be on the body.Now it is considered that aging is related to the injury of correlated brain areas caused by the excessive secretion of glucocorticoid.These areas not only involved in cognition and emotion,but also with other activities controlled by hypothalamus-pituitary-adrenal axis.In addition,differences in basal levels of cortisol,the availability of cortisol in brain,the imbalance of the glucocorticoid receptor,the vulnerability and the resilience of the brain itself are all the factors that affect brain aging.This review will give an account of the related mechanism and hypothesis for the stress response that leads to the normal or abnormal brain aging.更多还原