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应用分子靶向治疗的时机选择

Proper Timing of Apply Molecular-targeted Therapy

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【作者】 张凯赵瑞景陈连刚朱铁年

【Author】 ZHANG Kai;ZHAO Rui-jing;CHEN Lian-gang;Department of Oncology,Bethune International Peace Hospital;

【机构】 白求恩国际和平医院肿瘤科河北医科大学

【摘要】 分子靶向药物的出现显示出肿瘤治疗传统模式的重要进展。与传统放疗、化疗相比,分子靶向治疗因其特异性高、不良反应轻微,在恶性肿瘤个体化治疗中扮演重要角色。十五年来,分子靶向药物的出现,给肿瘤的治疗模式带来重大改变,也给临床医生带来新的挑战。准确把握分子靶向药物应用时机,获得最大临床效果,已成为肿瘤治疗领域关注热点。本文就非小细胞肺癌、消化系统肿瘤、乳腺癌、肾癌治疗中分子靶向药物如何选择应用时机进行阐述。

【Abstract】 The development of molecule-targeted therapy is a major breakthrough in the treatment of cancer.Compared with radiotherapy and chemotherapy,molecule-targeted therapy perform an important role in individually tailored cancer therapy because of the lower toxicity and higher efficiency.Over the recent 15years,the emergence of molecule-targeted therapy has brought great change to treatment of cancer,and also brought challenges to clinician.The timing of using the molecular-targeted therapy has become a heatedly-discussed issue.This review illustrated the issue from the perspective of molecular targeted therapies which were recommended for the cure of non small cell lung cancer,breast cancer,malignancies in digestive system and kidney cancer.

【基金】 国家自然科学基金,项目编号:81071846;河北省自然科学基金,项目编号:H2013505059;河北省科技厅国际合作项目,项目编号:12396107D;吴阶平基金,项目编号:320.6750.12604
  • 【文献出处】 医学与哲学(B) ,Medicine & Philosophy , 编辑部邮箱 ,2014年01期
  • 【分类号】R730.53
  • 【被引频次】8
  • 【下载频次】284
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