【摘要】 目的:分析帕瑞昔布在瑞芬太尼全身麻醉手术中的应用价值。方法:将接受瑞芬太尼全身麻醉的患者纳入研究,并随机分为观察组(接受帕瑞昔布镇痛)和对照组(接受等容量生理盐水),检测其术后疼痛、围术期炎性水平及苏醒期躁动情况。结果:1观察组接受帕瑞昔布镇痛,拔管后各个时间点的VAS疼痛评分均明显低于对照组,差异有统计学意义(t=5.291,t=3.267,t=6.182,t=4.392,t=2.643;P<0.05);2镇痛治疗前两组患者的炎性因子水平无明显差异,观察组接受帕瑞昔布镇痛后的白细胞介素IL-6、IL-8水平明显低于对照组,IL-10水平明显高于对照组;3观察组接受帕瑞昔布镇痛,拔管前后的躁动评分明显低于对照组,镇静评分明显高于对照组。结论:帕瑞昔布可以有效降低瑞芬太尼全身麻醉患者的术后疼痛感受,稳定围术期炎症因子水平,减少术后躁动。更多还原

【Abstract】 Objective: To analyze the effect of parecoxib on patients undergoing remifentanil anesthesia. Methods: Chosen patients undergoing remifentanil anesthesia between November 2012 to November 2013 as object of study, randomly divided into observation groups receiving parecoxib analgesia and control group receiving same volume of saline, testing their postoperative pain, inflammation levels and perioperative restlessness situation. Results: 1)Observation group patients various time points after extubation VAS pain scores were significantly lower than control group patients(t=5.291, t=3.267, t=6.182, t=4.392, t=2.643; P<0.05); 2)Two groups patients before treatment inflammatory cytokines level was no significant difference, observation groups patients after receiving parecoxib analgesia IL-6, IL-8 levels were significantly lower than control group,IL-10 levels was significantly higher; 3)Observation group patients pain score after extubation wew significantly lower than control group of patients,restlessness score was significantly higher. Conclusion: parecoxib can effectively reduce remifentanil anesthesia patients experience postoperative pain, stable perioperative inflammatory cytokines, reduce postoperative agitation.更多还原