【摘要】 采用硅胶、RP-18、Sephadex LH-20等多种材料进行分离纯化,通过理化方法和波谱分析进行结构鉴定,从担子菌薄皮干酪菌(Tyromyces chioneus)发酵液的乙酸乙酯提取部位分离并鉴定了4个化合物,它们分别为:tyromol A(1)、tyromol B(2)、15-hydroxy-6α,12-epoxy-7β,10αH,11βH-spiroax-4-ene(3)和agripilol C(4)。其中化合物1和2为新的倍半萜,化合物3和4均为首次从该真菌中分离得到。更多还原

【Abstract】 Two new sesquiterpenoids,named as tyromols A and B(1 and 2),were isolated from cultures of basidiomycete Tyromyces chioneus,along with two previously reported 15-hydroxy-6α,12-epoxy-7β,10αH,11βH-spiroax-4-ene(3) and agripilol C(4). Compounds 1-4 were separated and purified by silica gel,RP-18,Sephadex LH-20 column chromatography. Their structures were elucidated on the basis of extensive spectroscopic analysis including IR,MS,1D and 2D NMR experiments.更多还原