【摘要】 核交联聚合物胶束作为一种新型的递药系统,能减少药物在血液循环中的提前释放,提高胶束稳定性,可将药物有效地传递到治疗部位,进一步提高药物的生物利用度,降低毒副作用。大多数药物以物理包埋或者通过聚合物化学共价的方式存在于胶束内。由于聚合物的组成和性质具有多样性,以及机体内微环境特有的性质,可制备出具有环境响应性、主动靶向作用的核交联聚合物胶束,达到控制药物释放的目的。本文主要介绍了近年来各种类型的核交联聚合物胶束研究进展,分析并总结其作为药物传递系统的特点和作用。更多还原

【Abstract】 The core-crosslinked polymeric micelles were used as a new drug delivery system,which can decrease the premature drug release in blood circulation,improve the stability of the micelles,and effectively transport the drug into the therapy sites.Then the drug bioavailability increased further,while the side effect reduced.Most drugs were physically entrapped or chemically covalent with the polymer in the internals of micelles.Based on the various constitutions and properties of polymeric micelles as well as the special characteristics of body microenvironment,the environment-responsive or active targeting core-crosslinked micelles were designed and prepared.As a result,the drug controlled release behavior was obtained.In the present paper,the research progress of all kinds of core-crosslinked micelles which were published in recent years is introduced.Moreover,the characteristic and application prospect of these micelles in drug delivery system are analyzed and summarized.更多还原