【摘要】 目的:探讨丙戊酸钠(VPA)对癫痫患儿体重及神经肽Y(NPY)的影响。方法:按照纳入标准收集我院神经内科门诊2011年5月-2013年5月首次诊断癫痫后VPA单药治疗的患儿48例作为实验组,于治疗前、治疗后1、3、6个月检测患儿体质量指数(BMI)及血清NPY水平,分析两者之间的关系。另选择健康儿童24例作为对照组。结果:实验组治疗后1、3、6个月BMI及血清NPY均呈现出上升趋势,且两者在各时间点均明显高于对照组,差异具有统计学意义(P<0.05)。结论:VPA能够使癫痫患儿血清NPY水平升高,导致患儿体重增加。更多还原

【Abstract】 Objective:To study the effect of valproic acid on body weight and serum neuropeptide Y level in pediatric patients with epilepsy.Methods:48 pediatric patients with epilepsy in experiment group who were selected according to the standard of selection during May 2011 to May 2013 were treated with VPA for 6 months.The parameters of body mass index(BMI)and serum neuropeptide Y levels were detected before treatment and 1,3,6 months after treatment, then investigated the association between them.24 healthy children were divided into the control group.Results:At 1,3, 6months after treatment in experiment group BMI and the serum neuropeptide Y both showed uptrend,which were significantly higher than those of their control group at the same time point(P<0.05).Conclusion:The serum neuropeptide Y level was increased after valproic acid treatment,which led the body weight of pediatric patients with epilepsy to increase.更多还原