【摘要】 首个噁唑烷酮类抗菌药利奈唑胺自2000年上市以来,其耐药性问题日趋严重,开发新型噁唑烷酮类抗菌药物成为研究热点之一。综述了近年来对利奈唑胺C环进行的结构改造及相关衍生物的研究进展,旨在为噁唑烷酮类抗菌药的深入研发提供参考。更多还原

【Abstract】 Since the fi rst oxazolidinone antibiotic linezolid was marketed in 2000, the problem of its drug resistance has been growing worse. The developments of new oxazolidinone compounds have become a research hotspot. The recent developments in structural modifi cations on ring C of linezolid and research on the related derivatives were reviewed so as to provide references for the further research and development of oxazolidinone antibiotics.更多还原