【摘要】 目的:探讨中国汉族人群5-羟色胺2A受体(Serotonin 2A receptor,5-HT2A受体)基因1438A/G多态性与海洛因依赖的关联性。方法:检索中国知网、万方、维普、Pub Med等中外数据库于建库至2014年3月公开发表的文献,收集有关中国汉族人群5-HT2A受体基因1438A/G(rs6311)多态性与海洛因依赖的病例对照研究,在评价纳入文献质量,提取有效数据后,使用Stata12.0软件进行Meta分析。结果:共纳入9项关于5-HT2A受体基因1438A/G(rs6311)多态性与海洛因依赖的病例对照研究,其中病例组2654人,对照组2089人。Meta分析结果显示:中国汉族人群5-HT2A受体基因1438A/G多态性与海洛因依赖之间无显著相关性(A VS.G:OR=1.05,95%CI=0.89-1.25;AA+AG VS.GG:OR=1.11,95%CI=0.84-1.47;AA VS.GG:OR=1.10,95%CI=0.57-1.57;AG VS.GG:OR=0.92,95%CI=0.71-1.18;AA VS.AG+GG:OR=1.02,95%CI=0.66-1.58)。Meta回归对异质性来源分析发现异质性主要来源于出版年份,基于地域的亚组分析显示:5-HT2A受体基因1438A/G多态性对于南方和北方人群的海洛因依赖风险无明显相关(南方:OR=0.95,95%CI=0.68-1.33;北方:OR=0.82,95%CI=0.49-1.37),敏感性分析显示Meta分析结果稳定,可信度较高。结论:中国汉族人群5-HT2A受体基因1438A/G多态性与海洛因依赖之间不存在关联性。更多还原

【Abstract】 Objective: To explore the association between 5- HT2 A receptor gene 1438 A / G polymorphism and heroin dependence in Chinese Han population.Methods: CNKI,Wanfang database,VIP,Pub Med and other foreign databases were searched for relevant articles published from database construction to march 2014. Case- control studies on 5- HT2 A receptor gene 1438 A / G( rs6311)polymorphism with heroin dependence in Chinese Han population were gathered with meta- analysis applied for STATA 12. 0 software after data abstraction.Results: We found nine case- control studies on association between 5- HT2 A receptor gene 1438 A / G polymorphism and heroin dependence,which included 2654 heroin dependence patients and 2089 controls. The finding of meta- analysis showed that5- HT2 A receptor gene 1438 A / G polymorphism didn’t increase the risk of heroin dependence in ChineseHan population( A VS. G: OR = 1. 05,95% CI = 0. 89- 1. 25; AA + AG VS. GG: OR = 1. 11,95%CI = 0. 84- 1. 47; AA VS. GG: OR = 1. 10,95% CI = 0. 57- 1. 57; AG VS. GG: OR = 0. 92,95%C = 0. 71- 1. 18; AA VS. AG + GG: OR = 1. 02,95% CI = 0. 66- 1. 58). Meta regression analysis of heterogeneity comes mainly from the year of publication,The results of subgroup analysis grouped by region showed that 5- HT2 A receptor gene 1438 A / G polymorphism had no correlation to the risk of heroin dependence of populations in the South and the North,and the results of the sensitivity analysis showed meta- analysis were stable and high reliability.Conclusion: The 5- HT2 A receptor gene 1438 A / G polymorphism is not associated with heroin dependence in Chinese Han population.更多还原