【摘要】 目的獉獉:探究M1受体的阻断剂及M4受体的激动剂对吗啡诱导的条件性位置偏爱表达的影响。方法獉獉:采用大鼠吗啡条件性位置偏爱(CPP)模型及脑部核团微注射的方法。结果獉獉:与生理盐水对照组相比,M1受体拮抗剂Pirenzepine可以增强吗啡CPP的表达,M4受体激动剂LY2033298也可以增强吗啡CPP的表达。结论獉獉:伏隔核的M1和M4型受体参与吗啡奖赏记忆的表达。更多还原

【Abstract】 Objective: To explore the roles of M1and M4muscarinic acetylcholinergic receptors in the expression of morphine- induced conditioned place preference( CPP). Methods: The model of morphine- induced CPP in rat and the microinjections into nucleus accumbens were adopted.Results: It was found that the antagonist of M1receptor( Pirenzepine) enhanced the expression of morphine-induced CPP,and that the agonist of M4receptor( LY2033298) also amplified the expression of morphine-induced CPP. Conclusion: The M1and M4receptors in nucleus accumbens play roles in the modulation of morphine reward memory.更多还原