【摘要】 目的:观察乙酰半胱氨酸牛磺酸镁盐对高脂饮食所致非酒精性脂肪性肝炎(NASH)模型大鼠脂质代谢的影响。方法:采用高脂饲料喂养12周复制大鼠NASH模型,成模后大鼠分为模型组、乙酰半胱氨酸牛磺酸镁盐低、中、高剂量治疗组和易善复阳性对照组。治疗8周后取血测定各组大鼠血清ALT、AST、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)。结果:与NASH模型组相比,各治疗组大鼠血清ALT、AST、TC、TG、LDL-C含量均明显降低,HDL-C含量显著升高,差异具有统计学意义(P<0.05),其中乙酰半胱氨酸牛磺酸镁盐中、高剂量组改善尤为显著。结论:乙酰半胱氨酸牛磺酸镁盐保护NASH大鼠作用通过降低血清转氨酶水平,改善血脂含量实现。更多还原

【Abstract】 AIM:To study the effect of ace- tylcysteine taurine magnesium salt [(NAC ·TA)Mg]on lipid metabolism in rats with non-alcoholic steatohepatitis(NASH).METHODS:95male SD rats were randomly divided into 2groups:the normal group,the model group.The experimental rats were given fat rich diet.The model of NASH was established after 12 weeks.All the rats were put to death after 8 weeks treatment,plasma sample was collected for the content detection of serum ALT,AST,triglyceride(TG),total cholesterol(TC),the high-density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C).RESULTS:Compared with the model group,the contents of ALT,AST,TG,TC or LDL-C were significantly decreased,the conten of HDL-C was increased,the differences had remarkable significance(P<0.05 or P<0.01).CONCLUSION:(NAC·TA)Mg can obviously decrease the content of bloodfat in rats with NASH.更多还原