【摘要】 目的:通过对血液内科住院老年肿瘤患者的研究,探讨感染病原菌分布和耐药性。方法:选取2010年2月-2014年2月到笔者所在医院住院治疗时并发感染的312例老年肿瘤患者。采集感染患者的血液512份,痰液205份,粪便61份,然后用全自动细菌培养仪对采集的标本进行培养,最后以MID(Microgen ID)细菌生化鉴定系统对病原菌的分布进鉴定(包括病原菌的种类和相应的菌株),及采用抗生素浓度梯度法做药物敏感性试验。结果:778份样本中,共分离出菌株135株,阳性率为17.35%。老年肿瘤患者感染病原菌的种类主要以革兰阴性菌、革兰阳性菌、真菌为主;其中革兰阴性菌又以大肠埃希菌、铜绿假单胞菌、克雷伯杆菌为主,革兰阳性菌以葡萄球菌、链球菌、肠球菌为主;无论是革兰阴性菌还是阳性菌,都对青霉素、哌拉西林产生一定的耐药性,而对亚胺培南类药物较敏感。结论:对于老年肿瘤患者,容易发生院感,并且他们对青霉素、哌拉西林产生一定的耐药性,而对亚胺培南等药物较敏感。故而在临床治疗时,应慎重合理的选择药物治疗,提高临床疗效,值得临床参考。更多还原

【Abstract】 Objective:To study the hospitalized elderly patients with blood cancer, and explore the distribution and drug resistance of pathogenic bacteria.Method:312 elderly patients with concurrent infections in cancer from February 2010 to February 2014 in our hospital were selected.Patients infected blood collected 512 copies,205 copies of sputum,stool samples 61 copies.Then automated bacterial culture system for the collection of specimens for culture was used.Finally MID(Microgen ID) into the bacterial biochemical identification system to identify the distribution of pathogens(including the type of pathogen and the corresponding strain),and drug susceptibility testing done using antibiotic concentration gradient method.Result:In 778 samples,135 strains were isolated,the positive rate was 17.35%.Elderly cancer patients infected with the pathogen species mainly Gram-negative bacteria,Gram-positive bacteria,fungi dominated.Yoyo which Gram-negative bacteria Escherichia coli,Pseudomonas aerations,Klebsiella based Gram-positive bacteria Staphylococcus,Streptococcus,Enterococcus based.Whether it is positive or Gram-negative bacteria strains were penicillin,piperacillin had some resistance,and impanel class more sensitive to the drug.Conclusion:For elderly cancer patients,prone to hospital infection.And penicillin,piperacillin have some resistance to them,but more sensitive to impanel drugs.Therefore in the clinical treatment should be carefully rational choice of drug therapy and improve clinical outcomes,is worthy of reference.更多还原