【摘要】 发展环状化合物的高效合成方法对药物分子、天然产物及其他功能有机分子的合成具有重要意义.近年来,叔膦促进下两种亲电试剂之间的环化反应,由于具有原料简单易得、反应条件温和、且无需金属参与等优点,同时为多种碳环及杂环化合物的合成提供了高效的新途径,因而受到了合成化学家的广泛关注.这类反应通常经过叔膦对亲电试剂进行亲核加成,产生两性离子活性中间体这一关键步骤来完成.根据两性离子的不同来源,综述了叔膦促进下缺电子联烯、Morita-Baylis-Hillman烯丙基化合物、缺电子烯烃与其他亲电试剂之间的环化反应.更多还原

【Abstract】 The development of highly efficient synthetic methods of cyclic compounds is of great significance in the syntheses of pharmaceutically active molecules, natural products and other functional organic molecules. Recently, phosphine-promoted annulations of two electrophiles, which provide highly efficient access to various carbo- and heterocycles, have attracted extensive interest from synthetic chemists due to their merits such as ready availability of starting materials, mild and metal-free conditions. Generally, this kind of annulation reaction proceeds through a key step to generate an active zwitterionic intermediate via nucleophilic addition of the phosphine to an electrophile. According to different sources of the zwitterions, this review summarizes the recent progress in phosphine-promoted annulations of electron-deficient allenes, Morita-Baylis-Hillman allylic adducts, and electron-deficient alkenes with other electrophiles.更多还原