【摘要】 目的探讨甲状腺不典型腺瘤的辅助诊断指标。方法采用组织芯片免疫组化法检测40例甲状腺滤泡癌、40例甲状腺腺瘤和40例甲状腺不典型腺瘤组织中β-半乳糖凝集素3(β-galectin-3)和上皮钙黏蛋白(E-cadherin)的表达。结果甲状腺不典型腺瘤组织中β-galectin-3阳性表达率低于甲状腺滤泡癌(52.5%vs.75.0%),但高于甲状腺腺瘤的30.0%(P<0.05);甲状腺不典型腺瘤组织中E-cadherin阳性表达率高于甲状腺滤泡癌(75.0%vs.30.0%),但低于甲状腺腺瘤的87.5%(P<0.05)。结论联合测定β-galectin-3和E-cadherin表达可初步诊断甲状腺不典型腺瘤和甲状腺滤泡癌。更多还原

【Abstract】 Objective To investigate the auxiliary diagnostic indexes used in the diagnosis of atypical thyroid adenoma.Methods Immunohistochemical SP method was used to examine the expressions ofβ-galectin-3and E-cadherin in 40 follicular thyroid carcinoma,40 thyroid adenoma and40 atypical thyroid adenoma.Results The expression ofβ-galectin-3 was significantly lower in atypical thyroid adenoma than that in follicular thyroid carcinoma(52.5% vs.75.0%),but higher than 30.0%in thyroid adenoma(P<0.05).The expression of E-cadherin was significantly higher in atypical thyroid adenoma than that in follicular thyroid carcinoma(75.0%vs.30.0%),but lower than87.5%in thyroid adenoma(P<0.05).Conclusion Combined detectionβ-galectin-3and E-cadherin is helpful in primary diagnosis of atypical thyroid adenoma and follicular thyroid carcinoma.更多还原