【摘要】 目的观察氯吡格雷联合阿司匹林治疗短暂性脑缺血发作(TIA)的临床疗效。方法符合诊断标准的94例TIA患者随机均分为两组。两组均给予常规治疗,包括降血糖、降血压及调节血脂等;观察组加用氯吡格雷和阿司匹林口服(第1天氯吡格雷300mg,其后每天75mg,共用14d;阿司匹林100mg/d,口服14d),对照组仅加用阿司匹林100mg/d,口服14d。比较两组治疗前后凝血酶原时间、部分活化凝血酶原时间、血小板计数和纤维蛋白原,并评定两组治疗后临床疗效。结果观察组总有效率为89.36%,高于对照组的63.83%(P<0.05);两组治疗前后凝血功能指标比较差异均无统计学意义(P>0.05)。结论氯吡格雷联合阿司匹林治疗TIA的临床疗效优于阿司匹林,且安全可行。更多还原

【Abstract】 Objective To observe the efficacy of combined use of clopidogrel and aspirin in the treatment of transient ischemic attack(TIA).Methods A total of 94patients with TIA was equally randomized into two groups.On the basis of conventional therapy including reducing blood glucose and blood pressure and regulating blood fat,the patients of group A were treated with additional clopidogrel and aspirin and those of group B with additional aspirin.Clopidogrel 300mg was given orally on the 1st day,which was followed by clopidogrel 75mg for 13days.Aspirin 100mg was used orally for 14days.The prothrombin time(PT),activated partial thromboplastin time(APTT),platelet count and fibrinogen(Fib)were determined before and after treatment.The efficacy of treatment and adverse effects were compared between two groups.Results The total effectiveness rate was higher in group A than that in group B(89.36% vs.63.83%)(P<0.05).There were no significant differences in PT,APTT,platelet count and Fib between two groups after treatment or between before and after treatment in both groups(P>0.05).Conclusion The efficacy of combined use of clopidogrel and aspirin is better than that of aspirin in the treatment of patients with TIA.更多还原