【摘要】 回顾性分析还原型谷胱甘肽(GSH)联合腺苷蛋氨酸治疗化疗药物引起肝损害的临床疗效。83例化疗患者随机分为联合组(n=43)和对照组(n=40),在预防性保肝药物应用基础上,对照组予GSH 180 mg静滴1次/d,联合组在对照组基础上加用腺苷蛋氨酸1.0 g静滴1次/d。两组疗程12 d。联合组较对照组疗效更佳,联合组总有效率95.35%,明显高于对照组80.00%(P<0.05)。联合腺苷蛋氨酸治疗化疗药物性肝损害临床疗效肯定,优于单用。更多还原

【Abstract】 Clinical efficacy of liver lesion with the treatment of reduced glutathione and ademetionine was analyzed retrospectively. 83 patients were randomly divided into two groups based on the application of preventive hepatoprotective drug. Control group was treated with reduced glutathione intravenous drip infusion once a day( n = 40),while treatment group with reduced glutathione and ademetionine( Transmetil) once a day( n = 43). After 12 days,the clinical efficacy of treatment group was better than that of control group. Total response rate was 95. 35% for treatment group,much better than that of control group( 80. 00%). There was significant difference between two groups( P < 0. 05). Reduced glutathione and ademetionine are more effective in the treatment of chemotherapeuticsinduced liver lesion than only with reduced glutathione.更多还原