【摘要】 目的了解四川省结核分枝杆菌耐药状况,分析耐药趋势,为临床治疗和结核病防治规划提供科学依据。方法对四川省2010-07/2012-12开展耐药监测获得的1 313株结核分枝杆菌使用比例法进行异烟肼(INH)、链霉素(SM)、利福平(RFP)、乙胺丁醇(EMB)、卡那霉素(KM)和氧氟沙星(OFX)6种抗结核药的药物敏感实验。结果 1 313株结核分枝杆菌总耐药率为22.62%(297/1 313),其中初治涂阳患者总耐药率17.35%(185/1 066),复治涂阳患者总耐药率为49.34%(112/227),单耐药率为10.36%(136/1 313),多耐药率为4.27%(56/1 313),耐多药率为7.99%(105/1 313),其中5例广泛耐药菌株,广泛耐药率为0.38%(5/1 313);各种药物的耐药发生频率以INH最高,KM最低。结论与四川省2010年全国第五次结核病流行病学抽样调查数据相比,四川省结核病总耐药率、单耐药率、多耐药率均小幅下降,耐多药率上升,耐药率仍维持较高水平,提示四川省的耐药结核病防控工作面临的形势还很严峻,应继续加强结核病耐药监测与防治工作。更多还原

【Abstract】 Objective To understand the status of drug resistances of mycobacterium tuberculosis in Sichuan and to provide scientific evidences for tuberculosis control and clinical treatment. Methods Totally 1 313 strains of mycobacterium tuberculosis were collected through drug resistance surveillance in Sichuan during July 2010 and December 2012,and were identified in terms of drug resistances spectrum with 6 kinds of anti-TB drugs by proportional method,including isoniazide,streptomycin,rifampicin,ethambutol,kanamycin and ofloxacin. Results The total drug resistance rate of mycobacterium tuberculosis was 22. 62%( 297 /1313). The other drug resistance rates were specifically: new smear-positive cases,17. 35%( 185 /1066); previously treated smear-positive cases,49. 34%( 112 /227); the mono-resistance rate,10. 36%( 136 /1313); multiple drug-resistance rate,4. 27%( 56 /1313); MDR-TB,7. 99 %( 105 /1313) and XDR-TB,0. 38%( 5 /1313). INH was the most high resistance while KM for the last. Conclusion The total drug resistance rate and the mono-resistance rate both have slightly decreased from 2010,while multiple drug-resistance rate is on rise. The drug resistances are still at a high level as a whole and thus drug resistant surveillance on TB and corresponding control measures should be strengthened continuously.更多还原