【摘要】 [目的]观察发酵人参对四氧嘧啶诱导的糖尿病小鼠血糖、血脂水平及体质量的影响.[方法]给体质量为18~22g的昆明种小鼠一次性腹腔注射给予2.2%(质量分数)四氧嘧啶溶液220mg/kg,72h后检测空腹血糖值.选择血糖值介于11.1~26.1mmol/L的小鼠,按照血糖及体质量水平随机分成模型对照组、发酵人参大(0.70g/kg)、小(0.35g/kg)剂量组和二甲双胍(0.35g/kg)组,同时设正常对照组.连续灌胃给药18d后禁食12h,摘眼球取血液,分离血清测定血糖、胆固醇及三酰甘油水平.[结果]与模型对照组比较,发酵人参大、小剂量组小鼠血糖水平明显降低(P<0.01),体质量显著升高(P<0.01).模型对照组小鼠血清胆固醇水平与正常对照组比较明显降低(P<0.05),发酵人参大、小剂量组血清胆固醇水平与正常对照组比较差异无统计学意义(P>0.05).[结论]发酵人参对四氧嘧啶所致糖尿病小鼠有降低血糖作用,可改善糖尿病所致的体质量减轻及脂质代谢紊乱.更多还原

【Abstract】 OBJECTIVE To observe the effects of fermented ginseng on the level of blood glucose,blood lipid and body weight in alloxan(ALX)-induced diabetic mice.METHODS The 2.2% solution of ALX(220mg/kg)was injected into 18-22 g of Kunming mice intraperitoneally to induce the onset of diabetes mellitus(DM),and the fasting blood glucose was measured 72 hlater.Mice with the glucose level between 11.1mmol/L to 26.1mmol/L were taken as the successful model,and were randomly divided into five groups,including groups of normal control,DM model control,metformin group(0.35g/kg),high-dose(0.7g/kg)and low dose(0.35g/kg)of fermented ginseng.The contents of blood glucose and blood lipid in serum were detected after 18days’ intragastric administration with medicine at post-fasting 12 h.RESULTS The blood glucose content was obviously decreased and body weight was increased in both groups of fermented ginseng than in DM model group(P<0.01,P<0.05),and the content of cholesterol was significantly decreased in DM model group than in both groups of fermented ginseng(P<0.05),and had no significant difference between two groups(P>0.05).CONCLUSION The fermented ginseng may reduce the glucose content and improves the body loss and lipid metabolism disorder in ALX-induced DM mice.更多还原